Institutions: IBBA CNRhttps://orcid.org/0000-0001-9280-9437
I am trying to establish novel therapeutic avenues to cure a broad spectrum of rare diseases.
Each rare disease patient potentially benefitting from the therapeutic approach I propose carries a missense mutation in a glycoprotein gene. The mutation impairs fold of the mutate glycoprotein but does not abrogate its function (responsive mutation).
My idea is that modulators of Endoplasmic Reticulum glycoprotein folding Quality Control (ERQC) and/or of Endoplasmic Reticulum Associated Degradation ...
Institutions: CNR - Consiglio Nazionale delle Ricerchehttps://orcid.org/0000-0002-9238-3840
Expertise: Molecular and Cell Biology, Agricultural Sciences, Seed storage proteins, Organelle biogenesis, Proteostasis, Protein sorting and targeting, Plant Biotechnology, Protein Engineering, Bioinformatics
RESEARCH INTERESTS • Biogenesis and evolution of cellular compartments, mainly focused on synthesis and deposition of seed storage proteins: i) biogenesis of protein bodies in cereal seeds; ii) nutritional quality; ii) allergenic/antinutritional potential • Endoplasmic Reticulum Quality Control (ERQC) and Unfolded Protein Response (UPR) in plants • Membrane protein synthesis, sorting and targeting (channels/transporters; tail-anchored proteins) • Comparative Cell Biology • Molecular farming: ...