Projects: IBISBA 1.0 deliverables, PREP-IBISBA deliverables, Template library
Institutions: IBBA CNRhttps://orcid.org/0000-0001-9280-9437
Expertise: Structural biology, X-ray crystallography, Cryo-Electron Microscopy, Protein Structure, Eukaryotic secretion, Glycoprotein folding, Protein chemistry, Protein purification
Tools: Chromatography, FPLC, Recombinant protein expression, X-ray crystallography, Cryo-EM, Protein purification, Biochemistry and protein analysis
I am trying to establish novel therapeutic avenues to cure a broad spectrum of rare diseases.
Each rare disease patient potentially benefitting from the therapeutic approach I propose carries a missense mutation in a glycoprotein gene. The mutation impairs fold of the mutate glycoprotein but does not abrogate its function (responsive mutation).
My idea is that modulators of Endoplasmic Reticulum glycoprotein folding Quality Control (ERQC) and/or of Endoplasmic Reticulum Associated Degradation ...
Projects: Uncurated Protocols Library, PlanOvac, SULFOCEL
Institutions: CNR - Consiglio Nazionale delle Ricerchehttps://orcid.org/0000-0002-9238-3840
Expertise: Molecular and Cell Biology, Agricultural Sciences, Seed storage proteins, Organelle biogenesis, Proteostasis, Protein sorting and targeting, Plant Biotechnology, Protein Engineering, Bioinformatics
Tools: Genetic analysis, Genetic modification, Model organisms, Molecular Biology, PCR, Biochemistry and protein analysis, Cell biology, Cytometry and fluorescent microscopy, rtPCR
RESEARCH INTERESTS • Biogenesis and evolution of cellular compartments, mainly focused on synthesis and deposition of seed storage proteins: i) biogenesis of protein bodies in cereal seeds; ii) nutritional quality; ii) allergenic/antinutritional potential • Endoplasmic Reticulum Quality Control (ERQC) and Unfolded Protein Response (UPR) in plants • Membrane protein synthesis, sorting and targeting (channels/transporters; tail-anchored proteins) • Comparative Cell Biology • Molecular farming: ...