Projects

The ecological niche occupied by a fungal species, its pathogenicity and its usefulness as a microbial cell factory to a large degree depends on its secretome. Protein secretion usually requires the presence of a N- terminal signal peptide (SP) and by scanning for this feature using available highly accurate SP-prediction tools, the fraction of potentially secreted proteins can be directly predicted. However, prediction of a SP does not guarantee that the protein is actually secreted and current ...

Biogas Purification with Algae Culture under alkaline conditions

Enhanced production of BIOtech personal CARE antioxidants from dairy side-streams- Lactobionic by Pseudomonas taetrolens

Upscale of the biocatalytic transformation of Free Fatty Acids into high-value products

Co-Culture for improved lignocellulose fractionation and elicitation of enzymatic activies - Omics on co-culture of trichoderma reesei or Phanerochaete chrysosporium

A collection of protocols that have been curated and validated

Cyanotoxins Study using Fluorescence Correlation Spectroscopy

Structural colour is widely found in nature and is defined by at least partially ordered nanostructures which interact with light to create vivid, angle-dependent colour. Structural colour (SC) is quite distinct from chemical pigments and offers superior properties (intensity, resistance to bleaching, advanced optical effects) compared to pigments and dyes. SC is familiar to us, for example in the way the feathers of the peacock catch the light. SC was observed by Hook and Newten in the 17th ...

Done by Alan Williams

In this project we have, as general objective, the screening of few extremozymes from the thermophilic/anaerobic Caldicoprobacter algerensis strain [1] using genomic approach. The major specific goal of this project is the determination of the whole genome sequence of this strain followed by sequence assembly and annotation. We will then exploit the obtained sequence to identify potential ORFs encoding extremozymes with industrial interest. A particular interest will be done for CAZymes (Xylanase, ...

Optimisation of production of flavin-containing oxidoreductases for industrial application

Hydrolisis of pectic oligosaccharides from sugar beet pulp to galacturonic acid in an enzyme membrane reactor

Elucidation of Rhodococcus genes involved in the production of novel antiviral glycolipids by transcriptomics for future production optimisation

High-resolutions fluxomics of industrial cyanobacteria

Infant formula milk tries to mimic human milk as closely as possible, since it is well-known that breast milk has considerable implications in the development of the infant intestinal microbiota in the first years of life. Human milk is considered to be unique in terms of its content of complex oligosaccharides. They are abundant in human milk and their role in the development of intestinal flora blocking the attachment of pathogens and modulating immune system of the infant make them of great ...

This project collects together the IBISBA 1.0 deliverables

Default library of IBISBA related information, The contents will be categorized later.

Industrial-scale penicillin simulation (IndPenSim) is a first principles mathematical model of a Penicillium chrysogenum fermentation. The simulation was developed in Matlab and is freely available to download. The development of the simulation is discussed in the paper titled "The development of an industrial-scale fed-batch fermentation simulation" currently available to download: here (Journal of Biotechnology). The paper has recently been extended which include the addition of a simulated ...

The project is coordinated by the CNR (National Research Council). It started in November 2022, and during 30 (+6) months will carry out an ensemble of cross-disciplinary actions across the different environmental sub-domains, with the main aim to build the network of the Italian environmental Research Infrastructures, connect it to the user community and establish access, trough the ITINERIS HUB, to the vast array of knowledge, data, analytical tools, and service produced by the participating ...

This a test for future uploads of datasets related to a project.

Natural sunscreen with MAA as the active ingredient

Microalgal lipids are valuable compounds of growing interest for health applications in food, feed and pharmaceutical industries. Especially, very long-chain polyunsaturated fatty acids (VLC-PUFAs) such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA) are essential dietary components for animals and humans. Production of such nutritional and functional lipids from microalgae is a promising strategy, but still faces some challenges to make it cost-efficient. ...

Transcriptomic and proteomic analysis of a Cladosporium species for the disovery of novel LPMOs

Multienzymatic oxidation of glycerol

Construction of a P. putida KT2440 producing cis,cis-muconate from glucose, benzoate, or p-coumarate

The project, PAT4Nano (Process Analytical Technology Tools for Real-Time Physical and Chemical Characterization of Nanosuspensions) is funded from the European Union’s Horizon 2020 research and innovation programme under the Research and innovation actions (RIA). The activity is part of the DT-NMBP-08-2019: Real-time nano-characterisation technologies call. Nanosuspensions are a critical material type found in everything from pharmaceuticals, to inks, paints, and fine chemicals used in advanced ...

Calidris Bio aims to bring a technology to the market to produce microbial protein for feed and food purposes. Calidris Bio is developing a production process consisting of fermentation and conditioning of the microbial biomass. The fermentation process was optimised at lab-scale (2L fed-batch and continuous fermentation) with a productivity of 10g/L/h. The next step is to scale-up the process to pilot scale. A concomitant life cycle analysis will be performed to pinpoint hotspots thus improving ...

Plant-based bio-encapsulation strategies for oral veterinary vaccines

Expression of a PET-hydrolysing polyesterase in Pseudomonas putida

This project compiles all IBISBA-related policy notes and reports that are neither delivrables nor milestones, created for public dissemination.

The aim of the EU-funded project PREP-IBISBA is to create the conditions for IBISBA to become a fully operational European research infrastructure in the coming years. The project will help IBISBA define a business model, establish a long-range financial plan and identify suitable legal frameworks to support its operation.

This project make available the deliverables of the PREP-IBISBA project

Innovative methanol free promoter comparison for Pichia pastoris for scalable bioprocesses

Scale up of a fermentative protein production and purification process for cheese substitutes manufacturing

A collection of announcements and documents

A sandbox project to experiment in.

Scorpionism is a serious public health problem in tropical areas, especially in Africa, southern India, the Middle East, and Latin America. There are about 12 species of scorpions that are dangerous to humans and all belong to the Buthidae family. In particular, venom on scorpion Androctonus australis hector is particularly toxic to humans. Serotherapy uses antibodies or fragments of antibodies to target the neurotoxins of the scorpion venom. Nanobodies, camelid-derived antibodies, are more ...

Optimisation of the Spore-Display system for the mucosal delivery of drugs and antigens

Novel (ligno)cellulose degrading enzyme for expression in the thermoacidofilic Archaeon Sulfolobus acidocaldarius

Contribution to a better food system with the production of recombinant animal proteins via model-based optimization and bioreactor cultivation.

A project for templates for templates for data, protocols etc. and for their documentation and examples.

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Prof. Pinar Calik, from the Ankara University (Turkey) is one of the first IBISBA users, who was granted access to IBISBA facilities for her project on P. pastoris called TRANSCRIPTPROM. We were pleased to have prof. Pinar Calik, Head of the Chemical Engineering Department of the Ankara University (Turkey), at the mid-term EC review sharing her experience as one of the first IBISBA users.

Thanks to IBISBA prompt response after the submission of the application, and the network of IBISBA facilities, ...

Farming of shellfish and seaweed is still new in Denmark and on a commercial scale is primarily limited to the production of longline mussels. It is mainly for mussels, that aquaculture production rely on natural spatfall. For all other species, such as oysters and macroalgae, hatcheries for the production of spat or seeding material are necessary. A major bottleneck in all bivalve hatchery is the food production, both in term of quantity and quality.

The native European flat oysters, is a key ...

The collection of protocols that have not yet been curated by IBISBA WP6

Lipase cell-surface display in Yarrowia lipolytica for direct biofuel production

Reconstruction and validation of a metabolic model for the yeast Saccharomyces cerevisiae growing on glycerol as the sole carbon source