SEEK ID: https://ibisbahub.eu/people/223
Location:
Germany
ORCID: Not specified
Joined: 23rd Oct 2025
Expertise: Not specified
Tools: Not specified
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Real-time online monitoring of bioprocesses
Industrial biotechnology (IB) has the potential to create new markets while protecting the environment. With this in mind, the EU-funded BIOINDUSTRY 4.0 project will pave the way for IB to become a major manufacturing technology. Supporting the digitalisation of IB, the project will create new services delivered by European research infrastructure. These will address several challenges, focusing on the acceleration of bioprocess development pipelines. ...
Projects: Industrial-scale penicillin simulation, Scorpion antivenom nanobody production in Escherichia coli (Recombinant bispecific VHH), Production of the monoclonal antibody Trastuzumab in Komagataella phaffii (Pichia pastoris) for breast cancer treatment, Bioindustry4.0 Work Package 7: Tools for high-quality datasets, requisite for data-driven methods and services, Hybrid Physics-Informed Neural Networks for Efficient Computational Modeling: A Workflow Framework Applied to Schwanniomyces occidentalis, Saccharomyces cerevisiae, Pseudomonas putida use case, STAMM: Soft sensor moniToring and mAintenance framework for Machine learning Models, Pichia pastoris fermentation, Bioindustry4.0 Public dissemination, Bioindustry4.0 Work Package 2: Dissemination, Communication Exploitation and capacity building, Data Fabric Usage Demos, raw2ready, SCHEMA, Joint Action Research - INRAE-UAB in Pichia pastoris, Joint xylitol fermentations monitored by Kaiser and Timegate Raman devices, UAB - Komagataella phaffii Use Case, Bioindustry4.0 Work Package 5
Web page: https://www.bioindustry4.eu
The fermentations were carried out at Vito utilizing the experience of VTT. The fermentations were monitored by both Timegate and Kaiser Raman spectrometers. The substrates used were xylose and xylitol and the product xylitol. Dissolved oxygen, off-gas analysis were also carried out. Offline samples were taken for further analysis. Further pure-component and mixture samples of the used components in the expected concentration ranges were prepared and measured by both devices and serve as calibration ...
Programme: Bioindustry 4.0
Public web page: Not specified
Organisms: Not specified
Measurements using Ramen spectroscopy can be perturbed by ‘background’ fluorescence during fermentation originating from the organism, the feedstock, and/or the medium. Data from the ‘Ethanol Production’ use case involving an industrial strain of the yeast S. cerevisiae (RWTH) will investigate the various sources of fluorescence and their effects on fluorescence at the end of fermentation. New and collated datasets will be useful in the production, refinement, and verification of statistical, ...
Programme: Bioindustry 4.0
Public web page: https://www.bioindustry4.eu/
Organisms: Saccharomyces cerevisiae
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