Production of the monoclonal antibody Trastuzumab in Komagataella phaffii (Pichia pastoris) for breast cancer treatment
OverviewTrastuzumab is a monoclonal antibody used for targeted breast cancer treatment. The production of the monoclonal antibody, trastuzumab, by the yeast Komagataella phaffii (Pichia pastoris) production system is being studied by INRAE - TWB. The expression of the genes coding heavy and light chain of the antibody is controlled by two ethanol inducible promoters.
Programme: Bioindustry 4.0
SEEK ID: https://ibisbahub.eu/projects/89
Funding codes:- https://cordis.europa.eu/project/id/101094287
- Grant agreement ID: 101094287
- https://doi.org/10.3030/101094287
Public web page: Not specified
Organisms: Komagataella (aka pichia) pastoris
IBISBA PALs: No PALs for this Project
Project created: 20th Oct 2025
TagsRelated items
Projects: Scorpion antivenom nanobody production in Escherichia coli (Recombinant bispecific VHH), Production of the monoclonal antibody Trastuzumab in Komagataella phaffii (Pichia pastoris) for breast cancer treatment
Institutions: INSAT - Institut National des Science Appliquees de Toulouse, INRAE
https://orcid.org/0000-0001-8290-1635
Bioprocess engineer with extensive expertise in bioreactor process design, fermentation technologies, and protein production. Skilled in scaling up bioprocesses, experimental design, and process optimization.
Responsible of the Transnational Access of IBISBA1.0
Research Director at INRA Director Life Sciences at Toulouse White Biotechnology
Real-time online monitoring of bioprocesses
Industrial biotechnology (IB) has the potential to create new markets while protecting the environment. With this in mind, the EU-funded BIOINDUSTRY 4.0 project will pave the way for IB to become a major manufacturing technology. Supporting the digitalisation of IB, the project will create new services delivered by European research infrastructure. These will address several challenges, focusing on the acceleration of bioprocess development pipelines. ...
Projects: Industrial-scale penicillin simulation, Scorpion antivenom nanobody production in Escherichia coli (Recombinant bispecific VHH), Production of the monoclonal antibody Trastuzumab in Komagataella phaffii (Pichia pastoris) for breast cancer treatment, Bioindustry4.0 Work Package 7: Tools for high-quality datasets, requisite for data-driven methods and services, Hybrid Physics-Informed Neural Networks for Efficient Computational Modeling: A Workflow Framework Applied to Schwanniomyces occidentalis, Saccharomyces cerevisiae, Pseudomonas putida use case, STAMM: Soft sensor moniToring and mAintenance framework for Machine learning Models, Pichia pastoris fermentation, Bioindustry4.0, Bioindustry4.0 Work Package 2: Dissemination, Communication Exploitation and capacity building, Data Fabric Usage Demos
Web page: https://www.bioindustry4.eu
ROR ID: Not specified
Department: Not specified
Country: 
France
City: Paris
Web page: https://www.inrae.fr/en
