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Projects: IBISBA Library, Development Project, TRANSCRIPTPROM - Integrative and comparative analyses of response of Pichia pastoris, FLOX: FLavin-containing OXidoreductases, PlanOvac, Muconic Acid Production, HIGHFLUX, spreadsheet test, Example project, Multi-site aspergillus, Promoters 4 Pichia
Institutions: UNIMAN - The University of Manchester, CSIC - Agencia Estatal Consejo Superior de Investigaciones Cientificas, INSAT - Institut National des Science Appliquees de Toulouse, UAB - Universitat Autònoma de Barcelona, CNR - Consiglio Nazionale delle Ricerche, CEA - Commissariat a l'Energie Atomique et aux Energies Alternatives
Institutions: UAB - Universitat Autònoma de Barcelonahttps://orcid.org/0000-0001-5626-429X
Expertise: Metabolic engineering, metabolic modelling, systems biology, MFA, Mathematical Modelling, Fluxomics, Microbiology, Closed ecologycal systems, Pichia pastoris, photosynthetic bacteria, Kinetic modelling
Tools: Fermentation, Metabolomics, Model organisms, Microbiology, Mathematical Modelling, Matlab, ODE, Computational and theoretical biology, metabolic flux analysis, COBRA, Copasi, RAVEN, metabolic modelling
Projects: IBISBA Library, Development Project, FLOX: FLavin-containing OXidoreductases, PlanOvac, HIGHFLUX, SporeDel, Yeast Glycerol, Galambr, SULFOCEL, An inventory of the Aspergillus niger secretome by combining in silico predictions with shotgun proteomics data, spreadsheet test
Institutions: UNIMAN - The University of Manchester, UAB - Universitat Autònoma de Barcelona, CNR - Consiglio Nazionale delle Ricerche, INSAT - Institut National des Science Appliquees de Toulouse, VTT - Teknologian tutkimuskeskus VTT Oy, VITO - Vlaamse Instelling voor Technologisch Onderzoek N.V.
The ecological niche occupied by a fungal species, its pathogenicity and its usefulness as a microbial cell factory to a large degree depends on its secretome. Protein secretion usually requires the presence of a N- terminal signal peptide (SP) and by scanning for this feature using available highly accurate SP-prediction tools, the fraction of potentially secreted proteins can be directly predicted.
However, prediction of a SP does not guarantee that the protein is actually secreted and current
Authors: Machtelt Braaksma, Elena S Martens-Uzunova, Peter J Punt, Peter J Schaap
Date Published: 1st Dec 2010
Publication Type: Journal